Cohorts
STU-2026-089 — Phase III Oncology — Compound SYN-441
⇩ Ledger (PDF/A)
⇩ Allocation CSV
⇩ Safety CSV
⇩ Ledger CSV
CohortGrid holds each cohort's slots. Site staff reserve a slot for a screened candidate while
screening completes; a reservation lapses unless it is confirmed. Every reservation and release is written to the
audit ledger. This page updates as soon as anyone, at any site, changes a slot.
Dose level 1 DL1
Open
25 mg QD oral
3 slots: 3 available — plus 1 held back for replacements
168 h between first doses · 28-day DLT window
Safety gate open
No subject dosed yet: the first may be dosed.
Escalation (3+3):
Wait
3 place(s) at this dose are not yet evaluable: still to be filled, or a subject has not completed their DLT window.
-
Slot 1
Available
-
Slot 2
Available
-
Slot 3
Available
-
Replacement 4
Held back
Site staff with a role at an active site reserve slots. Sign in to reserve.
Dose level 2 DL2
Planned
50 mg QD oral
3 slots: 3 available — plus 1 held back for replacements
168 h between first doses · 28-day DLT window
Safety gate open
No subject dosed yet: the first may be dosed.
-
Slot 1
Available
-
Slot 2
Available
-
Slot 3
Available
-
Replacement 4
Held back
Dose level 3 DL3
Planned
100 mg QD oral
3 slots: 3 available — plus 1 held back for replacements
168 h between first doses · 28-day DLT window
Safety gate open
No subject dosed yet: the first may be dosed.
-
Slot 1
Available
-
Slot 2
Available
-
Slot 3
Available
-
Replacement 4
Held back
